So, the researchers analyzed the retinal ganglion cells next– which are responsible for receiving signals from photoreceptors.
And by using genetic silencing again, they were able to learn more about which cells were responsible for communicating with the thalamus.
Finally, the team tracked the neuro signaling while different light colors were shone into the eyes of mice. It was ultimately discovered that the green light caused more GABA signaling.
This GABA signaling sets off a domino effect by first leading to a higher expression of the Penk gene.
The Penk gene is responsible for encoding a protein known as PENK, which ultimately leads to a molecule known as ENK being created. Lastly, ENK is responsible for activating the brain’s opioid receptors– which leads to the reduction of pain.
So now, equipped with these findings, the research team now intends to set their sights on figuring out why exactly the brain has evolved to allow green light to reduce pain sensations.
To read the study’s complete findings, which have since been published in Science Translational Medicine, visit the link here.
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