A past study, which was performed in 2016 in Shanghai, revealed similar gender differences. That research found that the risk of type 2 diabetes among men with prediabetes was drastically reduced if they increased muscle mass and physical activity.
On the flip side, that study found that women who had prediabetes needed to avoid abdominal obesity and any increase in their waist circumference.
So, according to Kerstin Brismar, a professor of diabetes research, the latest study starts to explain why there was an observed preventive lifestyle gender difference in the 2016 research.
“The proteins we studied in men and women increase with increased muscle mass and physical activity (IGFBP-1) and with reduced abdominal obesity and calorie restriction (adiponectin),” Brismar said.
Additionally, the findings may also reveal why regular exercise is not enough to reduce type 2 diabetes risk among women with abdominal obesity.
“We have previously shown that waist circumference was a strong independent predictor of type 2 diabetes in women,” Brismar explained.
“And now, we were able to show that it was linked to reduced production of adiponectin, a protein/hormone produced in the adipose tissue to– among other things– protect against cell stress.”
To read the study’s complete findings, which have since been published in Frontiers in Endocrinology, visit the link here.
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