And amazingly, the researchers found that cognitive performance did increase in six out of the seven patients, resulting in a stronger understanding of instructions, episodic memory, attention, and improved reasoning.
These results were also confirmed via brain imaging performed by the CHUV Department of Clinical Neurosciences.
In turn, the researchers now believe that GnRH is critical in strengthening communication between various cortex regions.
“Maintaining the GnRH system appears to play a key role in brain maturation and cognitive functions. In Down syndrome, pulsatile GnRH therapy is looking promising, especially as it is an existing treatment with no significant side effects,” explained Vincent Prévot, the study’s lead researcher.
Now, the team hopes to launch a much larger study that includes women to confirm the efficacy of the treatment for people with Down syndrome, as well as other neurodegenerative conditions, including Alzheimer’s disease.
To read the study’s complete findings, which have since been published in Neurodevelopment, you can visit the link here.
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